TOR Complex 2-Ypk1 Signaling Maintains Sphingolipid Homeostasis by Sensing and Regulating ROS Accumulation
Reactive oxygen species (ROS) are produced during normal metabolism and can function as signaling molecules.However, ROS at elevated levels can damage cells.Here, we identify the conserved target of rapamycin complex 2 (TORC2)/Ypk1 signaling module as CLOVE OIL an important regulator of ROS in the model eukaryotic organism, S.cerevisiae.We show tha